I'm a CPA, and at my only stint with a (big) CPA firm, I used ProFx, which is top of the line software. It also costs 20k or more.
i do quite a few multi-state returns (I love multi state because I'm a frikkin masochist- yeah I seek out those suckers as a specialty) and I find ATX handles them just fine. When I find a situation that ATX can't handle, like when I had same sex couples that had to file an out of state return as single, I just copy the return and then change the filing status to do the oddball state, deleting what I don't need for that return. No need to input from scratch.
Also, the out of state tax credit calcs improved 100% in the last 2 years. They are much easier to do than they were in 2011.
All that said, if you are used to menu inputs like with Profx, Drake will not be much of an adjustment. But I will also stress that you MUST know when a return is correct. I have the all-states guide and go through a states instructions very carefully when doing one I'm not very familiar with, and look for oddball credits and deductions a state might have. And I always check to see if anything has changed on all the states I do.