I use a 17" Acer laptop with the pointer turned off and use the keyboard. This is not my main computer, BUT, could be. Any bookwork or returns prepared on the laptop are exported to a jump drive and imported into my desktop for revue and filing. Even with my diagnosis of Macular Degeneration; I don't, as yet, have a problem with the 17" screen and it is running Windows 11. I could add another monitor if I had the room. I also would need to get a wireless printer, but there is no need at this point. Each computer in my office has its own printer at the moment. Good luck with whichever way you choose to go. Generally, I believe that if I want to do something, such as tax prep, I will find a way to do it. So far, I haven't let age or left-handedness hold me back.